Torzemin 2 mg is a veterinary medicine indicated as an oral diuretic for dogs, containing torasemide as the active ingredient, a loop diuretic of the pyridine-3-sulfonylurea class. Torasemide acts on the ascending limb of the loop of Henle, blocking the sodium, potassium and chloride cotransport system (Na+-K+-2Cl-), which inhibits the active reabsorption of sodium and chloride and, consequently, the reabsorption of water in the collecting duct, promoting increased diuresis (urine elimination). Indications and use: Torzemin is mainly used for dogs with conditions that require increased fluid elimination, such as in cases of heart disease with high blood pressure and other situations that benefit from diuretic action. The recommended dose is 0.2 mg/kg administered orally every 12 hours, usually for 14 days, and treatment may be extended up to 28 days according to veterinary evaluation. Dosage (example for Torzemin 2 mg): Dogs weighing 2.5 kg: ¼ tablet every 12 hours Dogs weighing 5 kg: ½ tablet every 12 hours Dogs weighing 10 kg: 1 tablet every 12 hours Dogs weighing 15 kg: 1½ tablet every 12 hours The dose should be adjusted according to the animal's weight and veterinarian's instructions. Pharmacokinetics: Torasemide is rapidly absorbed orally, reaching peak plasma levels within 1 hour, with bioavailability between 76% and 92%. It is highly bound to plasma proteins and is metabolized in the liver, with renal excretion of metabolites. Adverse effects: Mild and transient effects may occur, such as decreased appetite, increased water intake, vomiting, loose stools, and reduced blood pressure without causing severe hypotension. Laboratory changes such as increased hematocrit, red blood cells, hemoglobin, albumin, serum creatinine, uremia, and reduced potassium and chloride levels are also observed. Increased diuresis can cause dehydration, so it is essential to keep the animal with free access to water. In diabetic dogs, it is recommended to monitor blood glucose levels, as torasemide can temporarily increase blood glucose levels. Precautions: Use in pregnant or lactating dogs, dogs for breeding, or puppies under 1 year of age is not recommended without veterinary evaluation. It is important to monitor renal function, electrolytes, hydration, and blood pressure during treatment. In summary, Torzemin 2 mg is an effective and safe diuretic for oral use in dogs, indicated to control fluid retention and high blood pressure, with a dose adjusted to weight and veterinary monitoring to avoid adverse effects.
